We used Golgi staining and neuroelectrophysiological techniques to detect structurally and functionally impaired synaptic plasticity in hippocampal CA1 region of Postoperative cognitive dysfunction aged mice, respectively. In this study, we observed hippocampus-dependent cognitive impairment in aged mice undergoing anesthesia and tibial fracture surgery, a common model of postoperative cognitive dysfunction in aged mice. The elderly are particularly vulnerable to brain dysfunction after fracture surgery, but the mechanism underlying the cognitive decline due to anesthesia/surgery is not well understood. 5NHC Key Laboratory of Intelligent Orthopaedic Equipment, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.4Department of Orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.3Department of Anesthesiology, Hebei Children’s Hospital Affiliated to Hebei Medical University, Shijiazhuang, Hebei, China.
2Teaching Experiment Center, Hebei Medical University, Shijiazhuang, Hebei, China.1Department of Anesthesiology, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.Xupeng Wang 1, Yanan Li 1, Juan Zhao 2, Jiaxu Yu 1, Qi Zhang 1,3, Fang Xu 1, Yahui Zhang 1, Qi Zhou 1, Chunping Yin 1, Zhiyong Hou 4,5 and Qiujun Wang 1 *
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